TAPBP Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2733221

Recombinant TAPBP protein expressed in HEK-293 Cells.

Quick Overview for TAPBP Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2733221)

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This TAPBP protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human Tapasin (TAPBP) (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TAPBP (TAP Binding Protein (Tapasin) (TAPBP))

Alternative Name: Tapasin (Tapbp)

Background: This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms.

Molecular Weight: 45.6 kDa

NCBI Accession: NP_003181