TPMT Protein (Myc-DYKDDDDK Tag)
Quick Overview for TPMT Protein (Myc-DYKDDDDK Tag) (ABIN2733577)
Target
See all TPMT ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This TPMT protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Thiopurine methyltransferase (TPMT) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (His tag)
custom-made TPMT Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thiopurine S-Methyltransferase (TPMT) (AA 1-240) protein (His tag)custom-made TPMT Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Thiopurine S-Methyltransferase (TPMT) (AA 1-245) protein (GST tag)TPMT Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Thiopurine S-Methyltransferase (TPMT) (AA 1-245) proteinTPMT Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure SDS
Thiopurine S-Methyltransferase (TPMT) (AA 4-244), (partial) protein (GST tag)TPMT Origin: Human Host: Escherichia coli (E. coli) Recombinant 95 % ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- TPMT (Thiopurine S-Methyltransferase (TPMT))
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Alternative Name
- Thiopurine Methyltransferase (Tpmt)
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Background
- This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
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Molecular Weight
- 28 kDa
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NCBI Accession
- NP_000358
Target
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