THRB Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
This Recombinant THRB protein is produced in HEK-293 Cells.
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Catalog No. ABIN2733597
$1,112.40
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20 μg
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United States
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Quick Overview for THRB Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag) (ABIN2733597)
Target
See all THRB Proteins
THRB
(Thyroid Hormone Receptor, beta (THRB))
Protein Type
Recombinant
Origin
Human
Source
HEK-293 Cells
Application
Antibody Production (AbP), Standard (STD)
Purity
> 80 % as determined by SDS-PAGE and Coomassie blue staining
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Protein Characteristics
- Transcript Variant 2
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Purification tag / Conjugate
- This THRB protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human THRB / ERBA2 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Thyroid Hormone Receptor, beta (THRB) (AA 1-461) protein (His tag)
custom-made THRB Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- THRB (Thyroid Hormone Receptor, beta (THRB))
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Alternative Name
- Thrb,erba2
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Background
- The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
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Molecular Weight
- 52.6 kDa
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NCBI Accession
- NP_001121648
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Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
Target
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