Uromodulin Protein (UMOD) (Transcript Variant 1) (Myc-DYKDDDDK Tag)
Quick Overview for Uromodulin Protein (UMOD) (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2735074)
Target
See all Uromodulin (UMOD) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- Transcript Variant 1
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Purification tag / Conjugate
- This Uromodulin protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Uromodulin (UMOD) (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Uromodulin (UMOD) (AA 25-120) protein (GST tag)
UMOD Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Uromodulin (UMOD) (AA 1-611) protein (GST tag)UMOD Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Uromodulin (UMOD) (AA 25-588) protein (His tag)UMOD Origin: Mouse Host: Yeast Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Uromodulin (UMOD)
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Background
- The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.
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Molecular Weight
- 67.1 kDa
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NCBI Accession
- NP_003352
Target
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