DLK1 Protein (AA 24-303) (Fc Tag)
Quick Overview for DLK1 Protein (AA 24-303) (Fc Tag) (ABIN2745649)
Target
See all DLK1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 24-303
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Purification tag / Conjugate
- This DLK1 protein is labelled with Fc Tag.
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Purpose
- DLK1 (human):Fc (human) (rec.)
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Cross-Reactivity
- Human
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Characteristics
- Signal peptide and extracellular domain of human DLK1 (aa 24-303) are fused at the C-terminus to the Fc portion of human IgG1.
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Endotoxin Level
- <0.01EU/μg purified protein (LAL test).
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Biological Activity Comment
- Inhibits adipogenesis of 3T3L-1 cells.
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delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-306) (Active) protein (His tag)
DLK1 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) (Active) protein (hFc Tag)DLK1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-305) (Active) protein (His tag)DLK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 25-383) protein (GST tag)DLK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) protein (His tag)DLK1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
delta-Like 1 Homolog (Drosophila) (DLK1) (AA 24-303) protein (His tag)DLK1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with 100 μL sterile water.
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Concentration
- 0.1 mg/mL
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Buffer
- Contains PBS + 0.02 % CHAPS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- DLK1 (delta-Like 1 Homolog (Drosophila) (DLK1))
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Alternative Name
- DLK1
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Background
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Protein Delta Homolog 1, Fetal Antigen 1, Preadipocyte Factor 1, Pref-1, FA1
The transmembrane and secreted protein delta-like 1 homolog (DLK1, Protein delta homolog 1, Preadipocyte factor 1, Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-alpha converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.
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Molecular Weight
- ~65kDa (SDS-PAGE)
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UniProt
- P80370
Target
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