CCL3 Protein
Quick Overview for CCL3 Protein (ABIN2830201)
Target
See all CCL3 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Sequence
- APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA
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Characteristics
- Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using human blood monocytes is in a concentration range of 10-100 ng/mL.
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Sterility
- 0.2 μm filtered
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- CCL3 (Chemokine (C-C Motif) Ligand 3 (CCL3))
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Alternative Name
- Ccl3
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Background
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Relevance: Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
Synonyms: Macrophage inflammatory protein 1-alpha, Small-inducible cytokine A3 -
Molecular Weight
- 7.9 kDa
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UniProt
- P50229
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Autophagy
Target
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