IL-6 Receptor Protein (AA 20-358)
Quick Overview for IL-6 Receptor Protein (AA 20-358) (ABIN2816729)
Target
See all IL-6 Receptor (IL6R) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 20-358
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Sequence
- Leu20 - Asp358, Accession # P08887.1
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Characteristics
- Biological Activity: The ED50, as determined by enhancing IL-6 activity using murine M1 cells, is less than 15 ng/mL.
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Sterility
- 0.2 μm filtered
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Interleukin 6 Receptor (IL6R) (AA 20-365) protein (His tag)
IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Interleukin 6 Receptor (IL6R) (AA 20-365) protein (Fc Tag)IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 Receptor (IL6R) (AA 229-468) protein (His-IF2DI Tag)IL6R Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 6 Receptor (IL6R) (AA 1-468) protein (GST tag)IL6R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4.
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Storage
- -20 °C
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- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
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Alternative Name
- IL6R
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Background
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Relevance: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis., Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
Synonyms: IL-6 receptor subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, Membrane glycoprotein 80 -
Molecular Weight
- 37.9 kDa
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UniProt
- P08887
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Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
Target
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