PCSK9 Protein (AA 30-691) (His tag)
Quick Overview for PCSK9 Protein (AA 30-691) (His tag) (ABIN2870601)
Target
See all PCSK9 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 30-691
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Purification tag / Conjugate
- This PCSK9 protein is labelled with His tag.
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Sequence
- AA 30-691
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 73 kDa. The protein migrates as 18 kDa and 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation and proteolytic digestion.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 35-694) (Active) protein (His tag)
PCSK9 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag)PCSK9 Origin: Human Host: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 151-811) (Active) protein (His tag)PCSK9 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag,AVI tag,Biotin)PCSK9 Origin: Human Host: HEK-293 Cells Recombinant >92 % as determined by reduced SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (Fc Tag)PCSK9 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 1-678) protein (GST tag)PCSK9 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) protein (His tag)PCSK9 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) protein (Fc Tag)PCSK9 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
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Alternative Name
- PCSK9
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Background
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
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Molecular Weight
- 13.9 kDa and 59.0 kDa
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UniProt
- G3GTK5
Target
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