FCGR2B Protein (AA 40-217) (His tag)
Quick Overview for FCGR2B Protein (AA 40-217) (His tag) (ABIN2870737)
Target
See all FCGR2B ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 40-217
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Purification tag / Conjugate
- This FCGR2B protein is labelled with His tag.
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Brand
- MABSol®
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Sequence
- AA 40-217
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.2 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) protein (His-Avi Tag,Biotin)
FCGR2B Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) protein (His-Avi Tag)FCGR2B Origin: Human Host: HEK-293 Cells Recombinant > 95 % by SEC-HPLC SDS, SEC-HPLC, SPR
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 40-217) (Active) protein (His tag)FCGR2B Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-224) (Active) protein (His tag)FCGR2B Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 45-154) protein (GST tag)FCGR2B Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 46-217) protein (His-IF2DI Tag)FCGR2B Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (Active) protein (His tag)FCGR2B Origin: Rat Host: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. ELISA Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (Active) protein (His-Avi Tag,Biotin)FCGR2B Origin: Mouse Host: HEK-293 Cells Recombinant > 97 % as determined by reducing SDS-PAGE. ELISA Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (AA 30-210) (Active) protein (His tag)FCGR2B Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. BLI Active
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (Active) protein (His tag)FCGR2B Origin: Mouse Host: HEK-293 Cells Recombinant > 98 % as determined by reducing SDS-PAGE. ELISA Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- FCGR2B (Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B))
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Alternative Name
- Fc gamma RIIB / CD32b
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Background
- Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
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Molecular Weight
- 22.2 kDa
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NCBI Accession
- NP_001070657
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, BCR Signaling
Target
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