IgA1 Protein
This Native IgA1 protein is produced in Human.
Catalog No. ABIN3119703
$289.23
Plus shipping costs $50.00, if applicable $20.00 dry ice
1 mg
Shipping to:
United States
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Quick Overview for IgA1 Protein (ABIN3119703)
Target
IgA1
Protein Type
Native
Origin
Human
Source
Human
Purity
> 95 %
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Purpose
- Immunoglobulin A1, Human Plasma (IgA1)
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Characteristics
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Human plasma-derived IgA.
The predominant IgA subclass in circulation, comprising 90% of total serum IgA. It functions as a pathogen neutralizer, immune complex clearance facilitator, and cytoxicity mediator.
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Application Notes
- For use in: IsoC
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 10 mM phosphate, pH 7.4, with 150 mM NaCl and 0.05% NaN3.
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Storage
- -80 °C
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Storage Comment
- -70°C or lower
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- IgA1
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Alternative Name
- Immunoglobulin A1
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Background
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Serum IgA1 is the predominant subclass of Immunoglobulin A in human circulation, comprising approximately 90% of total serum IgA. It eatures a distinctive hinge region with multiple O-linked glycans, distinguishing it structurally from IgA2. IgA1 serves critical immune functions by neutralizing pathogens, facilitating immune complex clearance, and mediating antibody-dependent cell-mediated cytotoxicity through FcαRI receptors on neutrophils and monocytes.
Aberrant glycosylation of IgA1 plays a central role in IgA nephropathy pathogenesis, where galactose-deficient IgA1 forms immune complexes that deposit in glomeruli, triggering kidney inflammation and damage. Additionally, IgA1 abnormalities are implicated in IgA vasculitis, celiac disease, and certain autoimmune conditions.
Target
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