Betacellulin Protein (BTC) (partial) (Fc Tag)
Quick Overview for Betacellulin Protein (BTC) (partial) (Fc Tag) (ABIN5608199)
Target
See all Betacellulin (BTC) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- partial
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Purification tag / Conjugate
- This Betacellulin protein is labelled with Fc Tag.
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Sequence
- Asp 32 - Tyr 111
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Endotoxin Level
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
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Betacellulin (BTC) (AA 1-178) protein (GST tag)
BTC Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Betacellulin (BTC) (AA 32-111) protein (His tag)BTC Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (Fc Tag)BTC Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Application Notes
- This recombinant protein can be used for WB.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- Betacellulin (BTC)
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Alternative Name
- Betacellulin
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Background
- Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic beta-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5 % , identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.
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Molecular Weight
- 36.5 kDa
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Gene ID
- 685
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UniProt
- P35070
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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