PD-L1 Protein (partial) (Fc Tag)

Catalog No. ABIN5608343

Recombinant PD-L1 protein expressed in HEK-293 Cells.

Quick Overview for PD-L1 Protein (partial) (Fc Tag) (ABIN5608343)

Target: PD-L1 (CD274 (PD-L1))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Application: Western Blotting (WB)

Purity: >95 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: partial

Purification tag / Conjugate: This PD-L1 protein is labelled with Fc Tag.

Sequence: Phe 19 - Thr 238

Endotoxin Level: Endotoxin level is less than 0.1 EU per ug by the LAL method.

Application Details

Application Notes: This recombinant protein can be used for WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Target Details

Target: PD-L1 (CD274 (PD-L1))

Alternative Name: PD-L1

Background: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Molecular Weight: 51.8 kDa

Gene ID: 60533

UniProt: Q9EP73

Pathways: Cancer Immune Checkpoints