ADAM17 Protein (partial) (His tag)
Quick Overview for ADAM17 Protein (partial) (His tag) (ABIN5608397)
Target
See all ADAM17 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- partial
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Purification tag / Conjugate
- This ADAM17 protein is labelled with His tag.
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Sequence
- Pro 18 - Asp 563
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Endotoxin Level
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
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ADAM Metallopeptidase Domain 17 (ADAM17) (AA 581-642) protein (mFc Tag)
ADAM17 Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 752-824) protein (His-IF2DI Tag)ADAM17 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 581-642) protein (Fc Tag)ADAM17 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) protein (GST tag)ADAM17 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 18-563) protein (His tag)ADAM17 Origin: Mouse Host: HEK-293 Cells Recombinant >85 % as determined by SDS-PAGE.
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Application Notes
- This recombinant protein can be used for WB.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 50 mM MES, 150 mM NaCl, pH 6.5
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
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Alternative Name
- ADAM17
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Background
- Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
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Molecular Weight
- 63.4 kDa
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Gene ID
- 11491
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UniProt
- Q9Z0F8
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Pathways
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
Target
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