Dihydrofolate Reductase Protein (DHFR) (AA 2-187) (His-SUMO Tag)
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- Target See all Dihydrofolate Reductase (DHFR) Proteins
- Dihydrofolate Reductase (DHFR)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-187
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Dihydrofolate Reductase protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE VYEKND
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product DHFR Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- Dihydrofolate Reductase (DHFR)
- Alternative Name
- DYR (DHFR Products)
- Synonyms
- DHFR Protein, F10_orf160 Protein, ECK0049 Protein, JW0047 Protein, tmrA Protein, cb595 Protein, zgc:86637 Protein, DDBDRAFT_0187132 Protein, DDBDRAFT_0230113 Protein, DDB_0187132 Protein, DDB_0230113 Protein, CG14887 Protein, Dmel\\CG14887 Protein, dhfr Protein, DHFRP1 Protein, DYR Protein, 8430436I03Rik Protein, AA607882 Protein, AI662710 Protein, AW555094 Protein, Dhfr1 Protein, confers resistance to sulfonamides Protein, dihydrofolate reductase Protein, dihydrofolate reductase DhfR Protein, Dihydrofolate reductase Protein, dhfr Protein, DHFR Protein, dhfR Protein, folA Protein, dfrA Protein, LOC707382 Protein, CNJ01940 Protein, DDB_G0286755 Protein, Dhfr Protein, Mesil_0096 Protein, Arch_0408 Protein, Fbal_3367 Protein, Ilyop_0482 Protein, Lbys_2007 Protein, Riean_0733 Protein, Mrub_1855 Protein, Poras_0766 Protein, Halhy_3552 Protein, Mesop_3614 Protein, LOC609048 Protein
- Background
- Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.
- Molecular Weight
- 37.3 kDa
- UniProt
- P00374
- Pathways
- Mitotic G1-G1/S Phases
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