ICP47 (AA 1-88), (full length) protein (His tag)

Catalog No. ABIN5714202

Recombinant protein expressed in Yeast.

Quick Overview for ICP47 (AA 1-88), (full length) protein (His tag) (ABIN5714202)

Target: ICP47

Protein Type: Recombinant

Origin: Herpes Simplex Virus (HSV)

Source: Yeast

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: full length, AA 1-88

Purification tag / Conjugate: His tag

Sequence: MSWALEMADT FLDTMRVGPR TYADVRDEIN KRGREDREAA RTAVHDPERP LLRSPGLLPE IAPNASLGVA HRRTGGTVTD SPRNPVTR

Purification: SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: ICP47

Target Type: Viral Protein

Background: Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. pty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.

Molecular Weight: 11.79 kDa

UniProt: P03170