WWTR1 Protein (AA 1-400) (His tag)
Quick Overview for WWTR1 Protein (AA 1-400) (His tag) (ABIN5853441)
Target
See all WWTR1 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-400
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Purification tag / Conjugate
- This WWTR1 protein is labelled with His tag.
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Sequence
- MGSSHHHHHH SSGLVPRGSH MGSMNPASAP PPLPPPGQQV IHVTQDLDTD LEALFNSVMN PKPSSWRKKI LPESFFKEPD SGSHSRQSST DSSGGHPGPR LAGGAQHVRS HSSPASLQLG TGAGAAGSPA QQHAHLRQQS YDVTDELPLP PGWEMTFTAT GQRYFLNHIE KITTWQDPRK AMNQPLNHMN LHPAVSSTPV PQRSMAVSQP NLVMNHQHQQ QMAPSTLSQQ NHPTQNPPAG LMSMPNALTT QQQQQQKLRL QRIQMERERI RMRQEELMRQ EAALCRQLPM EAETLAPVQA AVNPPTMTPD MRSITNNSSD PFLNGGPYHS REQSTDSGLG LGCYSVPTTP EDFLSNVDEM DTGENAGQTP MNINPQQTRF PDFLDCLPGT NVDLGTLESE DLIPLFNDVE SALNKSEPFL TWL
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WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 1-400) protein (His tag)
custom-made WWTR1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
WW Domain Containing Transcription Regulator 1 (WWTR1) (AA 1-400) protein (GST tag)WWTR1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
WW Domain Containing Transcription Regulator 1 (WWTR1) protein (Myc-DYKDDDDK Tag)WWTR1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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Denatured
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M uREA, 10 % glycerol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))
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Alternative Name
- WWTR1
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Background
- WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Recombinant human WWTR1 protein, fused to His-tag at N-terminus, was expressed in E.coli .
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Molecular Weight
- 46.5kDa (423aa)
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NCBI Accession
- NP_001161752
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UniProt
- Q9GZV5
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Pathways
- Regulation of Lipid Metabolism by PPARalpha
Target
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