CNTF Receptor alpha Protein (AA 23-342) (His tag)

Catalog No. ABIN5854746

This Recombinant CNTF Receptor alpha protein is produced in Baculovirus infected Insect Cells.

Quick Overview for CNTF Receptor alpha Protein (AA 23-342) (His tag) (ABIN5854746)

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Protein Type: Recombinant

Origin: Rat

Source: Baculovirus infected Insect Cells

Application: SDS-PAGE (SDS)

Purity: > 90% by SDS-PAGE

Product Details

Protein Characteristics: AA 23-342

Purification tag / Conjugate: This CNTF Receptor alpha protein is labelled with His tag.

Sequence: QKHSPQEAPH VQYERLGTDV TLPCGTASWD AAVTWRVNGT DLAPDLLNGS QLILRSLELG HSGLYACFHR DSWHLRHQVL LHVGLPPREP VLSCRSNTYP KGFYCSWHLS APTYIPNTFN VTVLHGSKMM VCEKDPALKN RCHIRYMHLF STIKYKVSIS VSNALGHNTT AITFDEFTIV KPDPPENVVA RPVPSNPRRL EVTWQTPSTW PDPESFPLKF FLRYRPLILD QWQHVELSNG TAHTITDAYA GKEYIIQVAA KDNEIGTWSD WSVAAHATPW TEEPRHLTTE AQAPETTTST TSSLAPPPTT KICDPGELSS LEHHHHHH

Endotoxin Level: < 1 EU per 1ug of protein (determined by LAL method)

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Target Details

Target: CNTF Receptor alpha (CNTFR) (Ciliary Neurotrophic Factor Receptor (CNTFR))

Alternative Name: CNTFR alpha

Background: Cntfr, also known as ciliary neurotrophic factor receptor subunit alpha, is a member of the type 1 cytokine receptor family. It mediates the biological action of CNTF. CNTF is a polypeptide hormone that supports the survival of neurons of the peripheral sensory, sympathetic, and ciliary ganglia at various stages in their development. CNTFR and its cognate ligand support the survival of neurons. The CNTF receptor complex is most closely related to, and shares subunits with the receptor complexes for interleukin-6 and leukemia inhibitory factor. The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous system and skeletal muscle. Recombinant rat Cntfr, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molecular Weight: 36.9 kDa (328aa)

NCBI Accession: NP_001003929

UniProt: Q08406

Pathways: JAK-STAT Signaling, Feeding Behaviour