Epigen Protein (AA 23-110) (His tag)
Quick Overview for Epigen Protein (AA 23-110) (His tag) (ABIN5855016)
Target
See all Epigen (EPGN) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 23-110
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Purification tag / Conjugate
- This Epigen protein is labelled with His tag.
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Sequence
- ADPAAVTVTP PITAQQGNWT VNKTEADNIE GPIALKFSHL CLEDHNSYCI NGACAFHHEL EKAICRCFTG YTGERCEHLT LTSYAVDSYE KHHHHHH
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Purification
- > 90% by SDS-PAGE
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Endotoxin Level
- < 1 EU per 1ug of protein (determined by LAL method)
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Epithelial Mitogen (EPGN) (AA 24-95) protein (His-IF2DI Tag)
EPGN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Epithelial Mitogen (EPGN) (AA 1-133) protein (GST tag)EPGN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Epithelial Mitogen (EPGN) (AA 23-110) protein (His tag)EPGN Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Epithelial Mitogen (EPGN) protein (Myc-DYKDDDDK Tag)EPGN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- Phosphate-Buffered Saline ( pH 7.4) containing 10 % glycerol
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- Epigen (EPGN) (Epithelial Mitogen (EPGN))
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Alternative Name
- Epigen
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Background
- EPGN, also known as epigen isoform 1, is a novel member of the epidermal growth factor superfamily. It is the last ligand of ErbB receptors and reveals intricate relationships between affinity and mitogenicity. It stimulated the proliferation of HaCaT cells, and this proliferation was blocked by an antibody to the extracellular domain of the receptor tyrosine kinase c-erbB-1. It also may constitute a novel molecular target for wound-healing therapy with its ability to promote the growth of epithelial cells. It has been reported to have high mitogenic activity but low affinity for its receptor. It has been reported in cancer specimens of the breast, bladder, and prostate. Recombinant human EPGN, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Molecular Weight
- 10.8 kDa (97aa)
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NCBI Accession
- NP_001257918
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Pathways
- RTK Signaling, EGFR Signaling Pathway
Target
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