TNFRSF6B Protein (AA 24-300) (Fc Tag)

Catalog No. ABIN6253317

This Recombinant TNFRSF6B protein is produced in CHO Cells.

Quick Overview for TNFRSF6B Protein (AA 24-300) (Fc Tag) (ABIN6253317)

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Protein Type: Recombinant

Origin: Human

Source: CHO Cells

Purity: >98 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 24-300

Purification tag / Conjugate: This TNFRSF6B protein is labelled with Fc Tag.

Purpose: DcR3 (human):Fc (human) (rec.)

Specificity: The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1.

Characteristics: Protein. The extracellular domain of human DcR3 (aa 24-300) is fused to the N-terminus of the Fc region of human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 %), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

Endotoxin Level: <0.06EU/μg protein (LAL test, Lonza).

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handling Advice: Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Target Details

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Alternative Name: DcR3

Background:

Alternate Names/Synonyms: Decoy Receptor 3, Tumor Necrosis Factor Receptor Superfamily Member 6B, TNFRSF6B, M68

Product Description: Decoy receptor 3 (DcR3, TNFRSF6B, M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31 % ), TNF-RII (29 %) and Fas (17 %) and is expressed in a variety of different tissues and at high levels in many malignant tumors. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.

UniProt: O95407