TNFRSF6B Protein (Fc Tag)

Catalog No. ABIN7198508

Product Details

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This TNFRSF6B protein is labelled with Fc Tag.

Purpose: Recombinant Human DCR3/TNFRSF6B Protein (Fc Tag)(Active)

Sequence: Met 1-His300

Characteristics: A DNA sequence encoding the human DCR3 (O95407)(Met1-His300) was expressed with the Fc region of human IgG1 at the C-terminus.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells.The ED50 for this effect is typically 0.01-0.05 μg/mL in the presence of 20 ng/mL recombinant human Fas Ligand.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, pH 7.0.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: TNFRSF6B (Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B))

Alternative Name: DCR3/TNFRSF6B (TNFRSF6B Products)

Synonyms: DCR3 Protein, DJ583P15.1.1 Protein, M68 Protein, M68E Protein, TR6 Protein, dcr3 Protein, m68 Protein, tr6 Protein, TNF receptor superfamily member 6b Protein, tumor necrosis factor receptor superfamily, member 11b Protein, regulator of telomere elongation helicase 1 Protein, TNF receptor superfamily member 6b L homeolog Protein, TNFRSF6B Protein, tnfrsf11b Protein, RTEL1 Protein, tnfrsf6b Protein, tnfrsf6b.L Protein

Background:

Background: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This protein is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Synonym: DCR3,DJ583P15.1.1,M68,M68E,TNFRSF6B,TR6

Molecular Weight: 56.4 kDa

UniProt: O95407