IL-6 Receptor Protein (AA 20-357) (Fc Tag)
Quick Overview for IL-6 Receptor Protein (AA 20-357) (Fc Tag) (ABIN6253437)
Target
See all IL-6 Receptor (IL6R) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 20-357
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Purification tag / Conjugate
- This IL-6 Receptor protein is labelled with Fc Tag.
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Purpose
- IL-6R (mouse):Fc (mouse) (rec.)
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Specificity
- The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a.
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Characteristics
- Protein. The extracellular domain of mouse IL-6R (aa 20-357) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Interleukin 6 receptor (IL-6R, CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
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Endotoxin Level
- <0.06EU/μg protein (LAL test, Lonza).
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA.
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Interleukin 6 Receptor (IL6R) (AA 20-365) protein (His tag)
IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 6 Receptor (IL6R) (AA 20-365) protein (Fc Tag)IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, IA, ADA, AM
Interleukin 6 Receptor (IL6R) (AA 1-468) protein (GST tag)IL6R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 6 Receptor (IL6R) (AA 229-468) protein (His-IF2DI Tag)IL6R Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- Lot specific
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Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
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Handling Advice
- Avoid freeze/thaw cycles.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
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Alternative Name
- IL-6R
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Background
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Alternate Names/Synonyms: Interleukin-6 Receptor Subunit alpha, IL6RA, CD126
Product Description: Interleukin 6 receptor (IL-6R, CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
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Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
Target
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