TARDBP Protein (AA 1-414)
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- Target See all TARDBP Proteins
- TARDBP (TAR DNA Binding Protein (TARDBP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-414
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Sequence
- MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA EPKHNSNRQL ERSGRFGGNP GGFGNQGGFG NSRGGGAGLG NNQGSNMGGG MNFGAFSINP AMMAAAQAAL QSSWGMMGML ASQQNQSGPS GNNQNQGNMQ REPNQAFGSG NNSYSGSNSG AAIGWGSASN AGSGSGFNGG FGSSMDSKSS GWGM
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product TARDBP Protein
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TAR DNA Binding Protein (TARDBP) protein (Myc-DYKDDDDK Tag)
TARDBP Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
TAR DNA Binding Protein (TARDBP) (AA 1-260) protein (His tag)TARDBP Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 8-192) protein (His-IF2DI Tag)TARDBP Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 1-260) protein (GST tag)TARDBP Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
TAR DNA Binding Protein (TARDBP) (AA 1-414) protein (GST tag)TARDBP Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
TAR DNA Binding Protein (TARDBP) (AA 1-414) protein (Strep Tag)Crystallography grade TARDBP Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 1-414) protein (Strep Tag)Crystallography grade TARDBP Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
TAR DNA Binding Protein (TARDBP) (AA 1-396), (partial) protein (GST tag)TARDBP Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl( pH 8.0) containing 0.1M NaCl, 1 mM DTT, 1 mM EDTA, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- TARDBP (TAR DNA Binding Protein (TARDBP))
- Alternative Name
- TARDBP (TARDBP Products)
- Synonyms
- TARDBP Protein, TDP43 Protein, DKFZp459I2127 Protein, tardbp Protein, ALS10 Protein, TDP-43 Protein, 1190002A23Rik Protein, C85084 Protein, Tdp43 Protein, wu:fb77f02 Protein, wu:fc52g10 Protein, TAR DNA binding protein Protein, Tardbp protein Protein, TAR DNA binding protein L homeolog Protein, TAR DNA-binding protein 43-like Protein, TARDBP Protein, tardbp Protein, tardbp.L Protein, Tardbp Protein, LOC100621383 Protein
- Background
- TARDBP, as known as TAR DNA binding protein 43, was originally identified as a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. It has also been identified in individuals diagnosed with chronic traumatic encephalopathy, a condition that often mimics ALS and that has been associated with athletes who have experienced multiple concussions and other types of head injury. It has been shown to bind both DNA and RNA and have multiple functions in transcriptional repression, pre-mRNA splicing and translational regulation. Recombinant human TARDBP protein was expressed in E.coli and purified by using conventional chromatography.
- Molecular Weight
- 44.7 kDa (414 aa)
- NCBI Accession
- NP_031401
- UniProt
- Q13148
- Pathways
- Positive Regulation of Peptide Hormone Secretion
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