PARP1 Protein (AA 662-1014)
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- Target See all PARP1 Proteins
- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 662-1014
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Characteristics
- PARP1, 662-1014aa, Human, E.coli
- Purity
- > 95 % by SDS-PAGE
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Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 1-100) protein (GST tag)
PARP1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Poly (ADP-Ribose) Polymerase 1 (PARP1) (Active) protein (His tag)PARP1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE Active
Poly (ADP-Ribose) Polymerase 1 (PARP1) (N-Term) proteinPARP1 Origin: Human Host: Escherichia coli (E. coli) Ct
Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 2-331), (partial) protein (His tag)PARP1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris buffer(pH 8.0) containing 10% glycerol 1mM DTT.
- Storage
- 4 °C
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- Target
- PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
- Alternative Name
- PARP1 (PARP1 Products)
- Background
- PARP1 is a nuclear DNA-binding zinc finger protein which can exist as a homo- or hetero-dimer, and is strongly activated by DNA strand breaks. This protein involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP1 also plays a role in other cellular processes, including cell proliferation and differentiation. PARP-1 deficiencies lead to chromosomal instability due to higher frequencies of chromosome fusions and aneuploidy, suggesting that poly(ADPribosyl)ation contributes to the efficient maintenance of genome integrity. Recombinant PARP1 protein was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: ADPRT, ADPRT1, pADPRT, pADPRT-1, PARP, PARP-1, PPOL, Poly (ADP-ribose) polymerase family, member 1 ADP ribosyltransferase (NAD+, poly (ADP ribose) polymerase), ADPRT 1, msPARP, NAD(+) ADP ribosyltransferase 1, pADPRT 1, PARP 1, PARP1, Poly (ADP ribose) polymerase 1, poly(ADP ribose) synthetase, poly(ADP ribosyl)transferase, Poly[ADP ribose] synthetase 1, sPARP 1, sPARP1. NCBI no.: AAH37545
- Molecular Weight
- 39.6 kDa (354aa), confirmed by MALDI-TOF.
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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