GPC2 Protein (AA 24-552) (His tag)

Catalog No. ABIN6952277

Recombinant GPC2 protein expressed in HEK-293 Cells.

Quick Overview for GPC2 Protein (AA 24-552) (His tag) (ABIN6952277)

Target: GPC2 (Glypican 2 (GPC2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Rhesus Monkey

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 24-552

Purification tag / Conjugate: This GPC2 protein is labelled with His tag.

Sequence: AA 24-552

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Target Details

Target: GPC2 (Glypican 2 (GPC2))

Alternative Name: Glypican 2

Background: Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Molecular Weight: 59.9 kDa

NCBI Accession: XP_001103286

Pathways: Glycosaminoglycan Metabolic Process