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SARS-CoV-2 Spike (Super Stable Trimer) protein (His tag) Protein

Origin: SARS Coronavirus-2 (SARS-CoV-2) Host: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS. ELISA
Catalog No. ABIN6953299
$1,634.00
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  • Target See all SARS-CoV-2 Spike Proteins
    SARS-CoV-2 Spike
    Protein Type
    Recombinant
    Protein Characteristics
    Super Stable Trimer
    Origin
    • 131
    • 17
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    Source
    • 125
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This SARS-CoV-2 Spike protein is labelled with His tag.
    Application
    ELISA
    Purpose
    SARS-CoV-2 S protein, His Tag, Super stable trimer (MALS verified)
    Sequence
    AA 16-1213
    Characteristics
    SARS-CoV-2 S protein, His Tag, Super stable trimer is the ectodomain of SARS-CoV-2 S protein which contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
    Purity
    > 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-MALS.
    Sterility
    0.22 μm filtered
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Application Notes
    This product is specifically designed for serological test development.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS
    Storage
    -80 °C
    Storage Comment
    The product MUST be stored at -70°C or lower upon receipt.
    Expiry Date
    3 months
  • Target
    SARS-CoV-2 Spike
    Abstract
    SARS-CoV-2 Spike Products
    Synonyms
    E2, E2 glycoprotein precursor, Surface Glycoprotein, S
    Target Type
    Viral Protein
    Background
    It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Molecular Weight
    138.0 kDa
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