SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (N501Y, RBD) (Fc Tag)

Catalog No. ABIN6961042

This Recombinant SARS-CoV-2 Spike protein is expressed in HEK-293 Cells.

Quick Overview for SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (N501Y, RBD) (Fc Tag) (ABIN6961042)

Target: SARS-CoV-2 Spike (SARS-CoV-2 S)

Protein Type: Recombinant

Origin: SARS Coronavirus-2 (SARS-CoV-2)

Source: HEK-293 Cells

Product Details

Protein Characteristics: N501Y, RBD

Purification tag / Conjugate: This SARS-CoV-2 Spike protein is labelled with Fc Tag.

Purpose: SARS-CoV-2 Spike Protein RBD (Mammalian, N501Y, C-Fc)

Characteristics: Recombinant 2019-nCoV S-RBD is produced by Mammalian expression system and the target gene encoding Arg319-Ser541(N501Y) is expressed with a Fc tag at the C-terminus.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Target Details

Target: SARS-CoV-2 Spike (SARS-CoV-2 S)

Alternative Name: SARS-CoV-2 S Protein

Target Type: Viral Protein

Background: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell during the initial stages of the infection process. The SARS-CoV-2 Spike Protein mediates the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. SARS-CoV-2 infects the human respiratory epithelial cells through interaction with the human ACE2 receptor. The Spike Protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The Spike Protein plays key a part in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.