CD28 Protein (CD28) (AA 19-152) (His tag,mFc Tag)
Quick Overview for CD28 Protein (CD28) (AA 19-152) (His tag,mFc Tag) (ABIN6961087)
Target
See all CD28 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 19-152
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Purification tag / Conjugate
- This CD28 protein is labelled with His tag,mFc Tag.
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Purpose
- Recombinant human CD28 protein with C-terminal mouse Fc and 6xHis tag
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Specificity
- CD28(Asn19-Pro152) mFc(Pro99-Lys330) 6xHis
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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CD28 (CD28) (AA 19-152) (Active) protein (His-Avi Tag)
CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
CD28 (CD28) (AA 19-152) (Active) protein (Biotin,His-Avi Tag)CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
CD28 (CD28) (AA 19-152) (Active) protein (hFc-DYKDDDDK Tag)CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD28 (CD28) (AA 19-152) (Active) protein (Fc Tag)CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD28 (CD28) (AA 19-152) (Active) protein (Fc Tag,AVI tag,Biotin)CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
CD28 (CD28) (Active) protein (His tag)CD28 Origin: Human, Cynomolgus Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
CD28 (CD28) (AA 19-152) (Active) protein (mFc Tag)CD28 Origin: Human, Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD28 (CD28) (AA 18-153) (Active) protein (His tag)CD28 Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD28 (CD28) (AA 18-153) (Active) protein (mFc Tag)CD28 Origin: Dog Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
CD28 (CD28) (Active) protein (Biotin)CD28 Origin: Human, Cynomolgus Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE. Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- CD28
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Alternative Name
- CD28
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Background
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CD28,Tp44
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Molecular Weight
- predicted molecular mass of 68-72 kDa after removal of the signal peptide.
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Gene ID
- 940
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UniProt
- P10747
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Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Target
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