TNFRSF4 Protein (AA 29-214) (His tag,Fc Tag)
Quick Overview for TNFRSF4 Protein (AA 29-214) (His tag,Fc Tag) (ABIN6961095)
Target
See all TNFRSF4 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 29-214
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Purification tag / Conjugate
- This TNFRSF4 protein is labelled with His tag,Fc Tag.
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Purpose
- Recombinant human OX40 protein with C-terminal human Fc and 6xHis tag
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Specificity
- OX40(Leu29-Ala214) hFc(Glu99-Ala330) 6xHis tag
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 20-211) (Active) protein (Biotin,His-Avi Tag)
TNFRSF4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 20-211) (Active) protein (His-Avi Tag)TNFRSF4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His-Avi Tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (Biotin,His-Avi Tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His tag,AVI tag,Biotin)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 31-130) protein (GST tag)TNFRSF4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (Active) protein (His tag)TNFRSF4 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) protein (His tag)TNFRSF4 Origin: Cynomolgus Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (hFc Tag,Biotin)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
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Application Notes
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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Comment
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please see Certificate of Analysis for specific instructions of reconstitution.
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
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Alternative Name
- OX40
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Background
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TNFRSF4,OX40,CD134,OX40L receptor,ACT35,TXGP1L
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4 T cell response, as well as in T cell-dependent B cell proliferation and differentiation. -
Molecular Weight
- predicted molecular mass of 47.2 kDa after removal of the signal peptide.
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Gene ID
- 7293
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UniProt
- P43489
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Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
Target
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