IL-6 Receptor Protein (AA 20-365) (His tag)
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- Target See all IL-6 Receptor (IL6R) Proteins
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 20-365
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This IL-6 Receptor protein is labelled with His tag.
- Application
- ELISA
- Purpose
- Recombinant Human IL6R Protein with C-terminal 6xHis tag
- Specificity
- IL6R (Leu20-Pro365) 6xHis tag
- Characteristics
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Purity
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Interleukin 6 Receptor (IL6R) (AA 20-365) protein (Fc Tag)
IL6R Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 Receptor (IL6R) (AA 229-468) protein (His-IF2DI Tag)IL6R Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 6 Receptor (IL6R) (AA 1-468) protein (GST tag)IL6R Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Expiry Date
- 12 months
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- Target
- IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
- Alternative Name
- IL6R (IL6R Products)
- Background
- This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
- Molecular Weight
- predicted molecular mass of 39.4 kDa after removal of the signal peptide.The apparent molecular mass of IL6R-His is 55-70 kDa due to glycosylation.
- Gene ID
- 3570
- UniProt
- P08887
- Pathways
- JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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