Ret Proto-Oncogene Protein (RET) (Fc Tag)
Quick Overview for Ret Proto-Oncogene Protein (RET) (Fc Tag) (ABIN6964355)
Target
See all Ret Proto-Oncogene (RET) ProteinsProtein Type
Origin
Source
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Purification tag / Conjugate
- This Ret Proto-Oncogene protein is labelled with Fc Tag.
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Sequence
- RET (Leu29-Arg635)+hFc(GLU99-ALA330)
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Characteristics
- Tagged Protein: C-Human Fc tag
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Purification
- affinity purification
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Ret Proto-Oncogene (RET) (AA 25-458) protein (GST tag)
RET Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Ret Proto-Oncogene (RET) protein (DYKDDDDK Tag)RET Origin: Human Host: Insect cells (Sf9) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with deionized water
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Preservative
- Without preservative
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Storage
- -80 °C
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Storage Comment
- Store at -80°C for 12 months (Avoid repeated freezing and thawing)
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Expiry Date
- 12 months
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- Ret Proto-Oncogene (RET)
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Alternative Name
- RET
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Background
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Synonymes: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1
Description: This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017] -
Molecular Weight
- 92.29 kDa
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UniProt
- P07949
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Pathways
- RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
Target
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