IL1A Protein (AA 113-271) (Fc Tag)
Quick Overview for IL1A Protein (AA 113-271) (Fc Tag) (ABIN6964364)
Target
See all IL1A ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 113-271
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Purification tag / Conjugate
- This IL1A protein is labelled with Fc Tag.
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Purpose
- Recombinant Human IL1A Protein with C-terminal human Fc tag
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Specificity
- IL1A (Ser113-Ala271) hFc (Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- IL1A (Interleukin 1 alpha (IL1A))
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Alternative Name
- IL1A
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Background
- The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
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Molecular Weight
- predicted molecular mass of 44.2 kDa after removal of the signal peptide.The apparent molecular mass of IL1A-hFc is 35-55 kDa due to glycosylation.
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UniProt
- P01583
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Pathways
- NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
Target
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