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IL1A Protein (AA 113-271) (Fc Tag)

Recombinant IL1A protein expressed in HEK-293 Cells.
Catalog No. ABIN6964364

Quick Overview for IL1A Protein (AA 113-271) (Fc Tag) (ABIN6964364)

Target

See all IL1A Proteins
IL1A (Interleukin 1 alpha (IL1A))

Protein Type

Recombinant

Origin

  • 24
  • 12
  • 8
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Human

Source

  • 44
  • 13
  • 12
  • 2
  • 2
  • 2
  • 1
HEK-293 Cells

Purity

The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
  • Protein Characteristics

    AA 113-271

    Purification tag / Conjugate

    This IL1A protein is labelled with Fc Tag.

    Purpose

    Recombinant Human IL1A Protein with C-terminal human Fc tag

    Specificity

    IL1A (Ser113-Ala271) hFc (Glu99-Ala330)

    Characteristics

    Extracellular Domain Protein

    Purification

    Purified from cell culture supernatant by affinity chromatography
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    Expiry Date

    12 months
  • Target

    IL1A (Interleukin 1 alpha (IL1A))

    Alternative Name

    IL1A

    Background

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]

    Molecular Weight

    predicted molecular mass of 44.2 kDa after removal of the signal peptide.The apparent molecular mass of IL1A-hFc is 35-55 kDa due to glycosylation.

    UniProt

    P01583

    Pathways

    NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints
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