IL-18 Protein (AA 37-197) (Fc Tag)
Quick Overview for IL-18 Protein (AA 37-197) (Fc Tag) (ABIN6964366)
Target
See all IL-18 (IL18) ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 37-197
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Purification tag / Conjugate
- This IL-18 protein is labelled with Fc Tag.
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Purpose
- Recombinant Human IL18 with C-terminal human Fc tag
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Specificity
- IL18 (Thr37-Asp197) hFc (Glu99-Ala330)
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Characteristics
- Extracellular Domain Protein
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Purification
- Purified from cell culture supernatant by affinity chromatography
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Interleukin 18 (IL18) (AA 37-193) protein
IL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 18 (IL18) (AA 37-193) protein (Biotin)IL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 18 (IL18) (AA 37-193) protein (His-IF2DI Tag)IL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Interleukin 18 (IL18) (AA 36-192) protein (His tag)IL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Interleukin 18 (IL18) (AA 1-193) protein (GST tag)IL18 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Interleukin 18 (IL18) protein (His tag)IL18 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Interleukin 18 (IL18) protein (GST tag)IL18 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % as determined by reducing SDS-PAGE.
Interleukin 18 (IL18) (AA 37-197) protein (mFc Tag)IL18 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 18 (IL18) (AA 36-192) proteinIL18 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 90% by SDS-PAGE SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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Expiry Date
- 12 months
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- IL-18 (IL18) (Interleukin 18 (IL18))
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Alternative Name
- IL18
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Background
- The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]
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Molecular Weight
- predicted molecular mass of 44.3 kDa after removal of the signal peptide.The apparent molecular mass of IL18-hFc is 35-55 kDa due to glycosylation.
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UniProt
- Q14116
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Pathways
- Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
Target
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