PD-L1 Protein (AA 19-134) (His tag)
Quick Overview for PD-L1 Protein (AA 19-134) (His tag) (ABIN7013168)
Target
See all PD-L1 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 19-134
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Purification tag / Conjugate
- This PD-L1 protein is labelled with His tag.
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Characteristics
- Human PD-L1 / B7-H1 (19-134) Protein, His Tag (MALS verified)
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)HPLC verified PD-L1 Origin: Human Host: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
CD274 (PD-L1) (AA 19-238) protein (Fc Tag)PD-L1 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-237) protein (Fc Tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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Application Notes
- MALS verified
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- PD-L1 (CD274 (PD-L1))
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Alternative Name
- PD-L1
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Background
- Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
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Molecular Weight
- 15.2 kDa
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NCBI Accession
- NP_054862
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Pathways
- Cancer Immune Checkpoints
Target
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