GPC2 Protein (AA 24-554) (His tag)

Catalog No. ABIN7013370

This Recombinant GPC2 protein is produced in HEK-293 Cells.

Quick Overview for GPC2 Protein (AA 24-554) (His tag) (ABIN7013370)

Target: GPC2 (Glypican 2 (GPC2))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 24-554

Purification tag / Conjugate: This GPC2 protein is labelled with His tag.

Characteristics: Human Glypican 2 / GPC2 Protein, His Tag

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Target Details

Target: GPC2 (Glypican 2 (GPC2))

Alternative Name: Glypican 2

Background: Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Molecular Weight: 60.0 kDa

NCBI Accession: NP_689955

Pathways: Glycosaminoglycan Metabolic Process