PVRL4 Protein (AA 32-349) (Fc Tag)
Quick Overview for PVRL4 Protein (AA 32-349) (Fc Tag) (ABIN7013402)
Target
See all PVRL4 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 32-349
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Purification tag / Conjugate
- This PVRL4 protein is labelled with Fc Tag.
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Sequence
- AA 32-349
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Endotoxin Level
- Less than 0.1 EU per μg by the LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
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Alternative Name
- Nectin-4
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Background
- Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50 % , 49 % and 86 %o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.
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Molecular Weight
- 60.5 kDa
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NCBI Accession
- NP_112178
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Pathways
- Cell-Cell Junction Organization
Target
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