TNFSF13 Protein (AA 111-250) (His tag,DYKDDDDK Tag)
Quick Overview for TNFSF13 Protein (AA 111-250) (His tag,DYKDDDDK Tag) (ABIN7013494)
Target
See all TNFSF13 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 111-250
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Purification tag / Conjugate
- This TNFSF13 protein is labelled with His tag,DYKDDDDK Tag.
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Characteristics
- Human APRIL / TNFSF13 Protein, His,Flag Tag, active trimer (MALS verified)
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Application Notes
- MALS verified
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))
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Alternative Name
- APRIL
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Background
- APRIL(a proliferation-inducing ligand) is also known as Tumor necrosis factor ligand superfamily member 13, TALL-2, TRDL-1, CD256, TNFFSF 13, cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. APRIL is a cytokine of the tumor necrosis factor family associated mainly with hematologic malignancies. The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. BAFF-APRIL heteromers of different stoichiometries have distinct receptor-binding properties and activities. In addition, expression of APRIL was regulated by miR-145 in GC cells.
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Molecular Weight
- 50.2 kDa
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NCBI Accession
- NP_003799
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Target
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