STING/TMEM173 Protein (AA 99-330) (Fc Tag)

Catalog No. ABIN7092708

Recombinant STING/TMEM173 protein expressed in HEK-293 Cells.

Quick Overview for STING/TMEM173 Protein (AA 99-330) (Fc Tag) (ABIN7092708)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Purity: The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 99-330

Purification tag / Conjugate: This STING/TMEM173 protein is labelled with Fc Tag.

Purpose: Recombinant human TMEM173 protein with N-terminal Human Fc tag

Specificity: HFc(Glu99-Ala330) TMEM173 (Leu139-Ser379)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Application Notes: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Comment:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: TMEM173

Background: ERIS,hMITA,hSTING,MITA,MPYS,NET23,SAVI,STING,STING-beta,TMEM173
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

Molecular Weight: predicted molecular mass of 53.2 kDa after removal of the signal peptide.

Gene ID: 340061

UniProt: Q86WV6

Pathways: Activation of Innate immune Response