IL21 Receptor Protein (AA 20-232) (mFc Tag)

Catalog No. ABIN7092744

Recombinant IL21 Receptor protein expressed in HEK-293 Cells.

Quick Overview for IL21 Receptor Protein (AA 20-232) (mFc Tag) (ABIN7092744)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Protein Characteristics: AA 20-232

Purification tag / Conjugate: This IL21 Receptor protein is labelled with mFc Tag.

Purpose: Recombinant Human IL21R with C-terminal mouse Fc tag

Specificity: IL21R (Cys20-Glu232) mFc (Pro99-Lys330)

Characteristics: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Expiry Date: 12 months

Target Details

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: IL21R

Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Molecular Weight: predicted molecular mass of 50.7 kDa after removal of the signal peptide.The apparent molecular mass of IL21R-mFc is 55-70 kDa due to glycosylation.

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling