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CD74 Protein (Fc Tag)

This Recombinant CD74 protein is expressed in HEK-293 Cells.
Catalog No. ABIN7092797

Quick Overview for CD74 Protein (Fc Tag) (ABIN7092797)

Target

See all CD74 Proteins
CD74 (HLA-DR-gamma (CD74))

Protein Type

Recombinant

Origin

  • 14
  • 10
  • 3
Human

Source

  • 10
  • 9
  • 3
  • 2
  • 1
  • 1
  • 1
HEK-293 Cells

Purity

The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
  • Purification tag / Conjugate

    This CD74 protein is labelled with Fc Tag.

    Purpose

    Recombinant Human CD74(73-232) Protein with N-terminal human Fc tag

    Specificity

    HFc (Glu99-Ala330) CD74 (Gln73-Met232)

    Characteristics

    Extracellular Domain Protein

    Purification

    Purified from cell culture supernatant by affinity chromatography
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    Product
    Expression System
    Conjugate
    Origin
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    Expression System HEK-293 Cells
    Conjugate His tag
    Origin Human
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  • Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    Storage

    -20 °C,-80 °C

    Storage Comment

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    Expiry Date

    12 months
  • Target

    CD74 (HLA-DR-gamma (CD74))

    Alternative Name

    CD74

    Background

    The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

    Molecular Weight

    predicted molecular mass of 44.4 kDa after removal of the signal peptide.The apparent molecular mass of hFc-CD74(73-232) is 55-70 kDa due to glycosylation.

    UniProt

    P04233

    Pathways

    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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