Glucagon Receptor Protein (GCGR) (Fc Tag)

Catalog No. ABIN7121228

Product Details

Target: Glucagon Receptor (GCGR)

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This Glucagon Receptor protein is labelled with Fc Tag.

Purpose: Mouse GCGR / Glucagon receptor Protein, Fc Tag

Sequence: Ala 27 - Lys 137

Characteristics: Mouse GCGR, Fc Tag (GCR-M5254) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Lys 137 (Accession # Q61606-1).

Purity: >95 % as determined by SDS-PAGE.

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Application Notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.5 kDa. The protein migrates as 50-65 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: Glucagon Receptor (GCGR)

Alternative Name: GCGR / Glucagon receptor (GCGR Products)

Background: Synonyms: Glucagon R, GCGR,Glucagon receptor,
Description: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

Molecular Weight: 39.5 kDa

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process