PD-L1 Protein (His tag)
Quick Overview for PD-L1 Protein (His tag) (ABIN7121291)
Target
See all PD-L1 ProteinsProtein Type
Origin
Source
Purity
Grade
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Purification tag / Conjugate
- This PD-L1 protein is labelled with His tag.
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Purpose
- Canine PD-L1 / B7-H1 Protein, His Tag (MALS verified)
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Sequence
- Phe 19 - Arg 236
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Characteristics
- Canine PD-L1, His Tag (PDL-C52H4) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 236 (Accession # E2RKZ5-1).
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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CD274 (PD-L1) (AA 19-238) protein (Fc Tag)
PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His-Avi Tag,Biotin)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Cynomolgus, Rhesus Monkey Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (mFc-His Tag)PD-L1 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
CD274 (PD-L1) (AA 19-238) (Active) protein (His tag)HPLC verified PD-L1 Origin: Human Host: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active
CD274 (PD-L1) (AA 19-238) protein (Fc Tag)PD-L1 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-237) protein (Fc Tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD274 (PD-L1) (AA 19-238) protein (His tag)PD-L1 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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Application Notes
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-50 kDa under reducing (R) condition due to glycosylation.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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Storage Comment
- -20°C
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- PD-L1 (CD274 (PD-L1))
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Alternative Name
- PD-L1 / B7-H1
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Background
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Synonyms: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1,
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. -
Molecular Weight
- 26.6 kDa
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NCBI Accession
- NP_001278901
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Pathways
- Cancer Immune Checkpoints
Target
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