IL-4 Protein (Fc Tag)

Catalog No. ABIN7125955

This Recombinant IL-4 protein is expressed in HEK-293 Cells.

Quick Overview for IL-4 Protein (Fc Tag) (ABIN7125955)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Protein Type: Recombinant

Origin: Cynomolgus

Source: HEK-293 Cells

Purity: >90 % as determined by SDS-PAGE.

Grade: MALS verified

Product Details

Purification tag / Conjugate: This IL-4 protein is labelled with Fc Tag.

Purpose: Cynomolgus IL-4 Protein, Fc Tag (MALS verified)

Sequence: His 25 - Ser 153

Characteristics: Cynomolgus IL-4, Fc Tag is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # P79339-1).

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Application Notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.4 kDa. The protein migrates as 46-50 kDa and 53 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: IL-4

Background: Synonyms: IL4,BCGF1,BSF1,
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.

Molecular Weight: 41.4 kDa

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation