ACVA Protein (AA 311-426)

Catalog No. ABIN7319736

This Recombinant ACVA protein is produced in HEK-293 Cells.

Quick Overview for ACVA Protein (AA 311-426) (ABIN7319736)

Target: ACVA (Activin A (ACVA))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human, Mouse, Rat

Source: HEK-293 Cells

Application: Cell Culture (CC)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 311-426

Purpose: Recombinant Human/Mouse/Rat Activin A/INHBA Protein

Sequence: Gly311-Ser426

Characteristics: Recombinant Human/Mouse/Rat Activin A is produced by our Mammalian expression system and the target gene encoding Gly311-Ser426 is expressed.

Sterility: 0.2 μm filtered

Endotoxin Level: < 0.01 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to induce SMAD signaling in 293-Activin A Res cells. The ED₅₀ for this effect is 1.3 ng/ml.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: ACVA (Activin A (ACVA))

Alternative Name: Activin A/INHBA

Background: Activin A,INHBA,Inhibin beta A chain,Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.

Molecular Weight:

Calculated MW: 13 kDa

Observed MW: 15 kDa

Gene ID: 3624

UniProt: P08476

Pathways: Hormone Transport, Peptide Hormone Metabolism