ALPL Protein (His tag)
Quick Overview for ALPL Protein (His tag) (ABIN7318146)
Target
See all ALPL ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This ALPL protein is labelled with His tag.
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Purpose
- Recombinant Human Alkaline Phosphatase/ALPL Protein (His Tag)
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Sequence
- Leu18-Ser502
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Characteristics
- Recombinant Human Alkaline Phosphatase, Tissue-Nonspecific Isozyme is produced by our Mammalian expression system and the target gene encoding Leu18-Ser502 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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Alkaline Phosphatase, Liver/bone/kidney (ALPL) (AA 19-113) protein (His-IF2DI Tag)
ALPL Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Alkaline Phosphatase, Liver/bone/kidney (ALPL) (AA 91-200) protein (GST tag)ALPL Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Alkaline Phosphatase, Liver/bone/kidney (ALPL) (AA 1-524) protein (GST tag)ALPL Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Alkaline Phosphatase, Liver/bone/kidney (ALPL) (AA 19-503) (Active) protein (His tag)ALPL Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 95% by SDS-PAGE SDS, EAA Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, 2 mM MgSO4, 0.1 mM ZnCl2, pH 7.5.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
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Alternative Name
- Alkaline Phosphatase/ALPL
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Background
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Background: Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family. There are at least four distinct but related alkaline phosphatases in humans: intestinal AP (IAP), placental AP(PLAP), germ cell AP (GCAP) and their genes are clustered on chromosome 2, tissue-nonspecific isozyme (TNAP) which gene is located on chromosome 1. Alkaline phosphatases (APs) are dimeric enzymes, it catalyze the hydrolysis of phosphomonoesters with release of inorganic phosphate. The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor. This isozyme may play a role in skeletal mineralization. Mutations in ALPL gene have been linked directly to different forms of hypophosphatasia,characterized by poorly mineralized cartilage and bones, and this disorder can vary depending on the specific mutation since this determines age of onset and severity of symptoms.
Synonym: Alkaline Phosphatase, Tissue-Nonspecific Isozyme, AP-TNAP, TNSALP, Alkaline Phosphatase Liver/Bone/Kidney Isozyme, ALPL,HOPS,TNAP
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Molecular Weight
- 54.5 kDa
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UniProt
- P05186
Target
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