BLK Protein (His tag)
-
- Target See all BLK Proteins
- BLK (B Lymphoid Tyrosine Kinase (BLK))
- Protein Type
- Recombinant
- Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BLK protein is labelled with His tag.
- Purpose
- Recombinant Human BLK Protein (His Tag)
- Sequence
- Gly2-Pro505
- Characteristics
- Recombinant Human Tyrosine-Protein Kinase BLK is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus.
- Purity
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product BLK Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
-
- Target
- BLK (B Lymphoid Tyrosine Kinase (BLK))
- Alternative Name
- BLK (BLK Products)
- Synonyms
- bltk Protein, si:dkey-33i22.2 Protein, zgc:136231 Protein, MODY11 Protein, BLK proto-oncogene, Src family tyrosine kinase Protein, B lymphoid kinase Protein, blk Protein, BLK Protein, Blk Protein
- Background
-
Background: Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Synonym: Tyrosine-Protein Kinase Blk, B Lymphocyte Kinase, p55-Blk, BLK,MODY11
- Molecular Weight
- 58.7 kDa
- NCBI Accession
- NP_001706
- Pathways
- Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
-