BLK Protein (His tag)
Quick Overview for BLK Protein (His tag) (ABIN7318106)
Target
See all BLK ProteinsProtein Type
Origin
Source
Purity
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Purification tag / Conjugate
- This BLK protein is labelled with His tag.
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Purpose
- Recombinant Human BLK Protein (His Tag)
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Sequence
- Gly2-Pro505
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Characteristics
- Recombinant Human Tyrosine-Protein Kinase BLK is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) protein (GST tag)
BLK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) protein (His-IF2DI Tag)BLK Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
B Lymphoid Tyrosine Kinase (BLK) (AA 1-505) protein (His tag)BLK Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 80 % SDS
B Lymphoid Tyrosine Kinase (BLK) (Active) protein (GST tag)BLK Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 88 % as determined by reducing SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4.
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Storage
- -20 °C
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Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- BLK (B Lymphoid Tyrosine Kinase (BLK))
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Alternative Name
- BLK
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Background
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Background: Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Synonym: Tyrosine-Protein Kinase Blk, B Lymphocyte Kinase, p55-Blk, BLK,MODY11
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Molecular Weight
- 58.7 kDa
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NCBI Accession
- NP_001706
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Pathways
- Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
Target
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