BCL6 Protein (AA 1-150) (His-TRX)
Quick Overview for BCL6 Protein (AA 1-150) (His-TRX) (ABIN7317419)
Target
See all BCL6 ProteinsProtein Type
Origin
Source
Purity
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Protein Characteristics
- AA 1-150
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Purification tag / Conjugate
- This BCL6 protein is labelled with His-TRX.
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Purpose
- Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)
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Sequence
- Met 1-Met 150
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Characteristics
- A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.
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Sterility
- 0.2 μm filtered
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Biological Activity Comment
- Not validated for activity
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B-Cell CLL/lymphoma 6 (BCL6) (AA 131-230) protein (GST tag)
BCL6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B-Cell CLL/lymphoma 6 (BCL6) (AA 1-174) protein (His-IF2DI Tag)BCL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
B-Cell CLL/lymphoma 6 (BCL6) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)BCL6 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile 20 mM Tris, 10 % glycerol, pH 8.0
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- BCL6 (B-Cell CLL/lymphoma 6 (BCL6))
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Alternative Name
- BCL6/B-cell CLL lymphoma 6
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Background
- BCL5;BCL6A;LAZ3;ZBTB27;ZNF51,The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.
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Molecular Weight
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Calculated MW: 34.2 kDa
Observed MW: 33 kDa
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Gene ID
- 604
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UniProt
- P41182
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Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus
Target
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