Cadherin 12 Protein (His tag)
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- Target See all Cadherin 12 Proteins
- Cadherin 12
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This Cadherin 12 protein is labelled with His tag.
- Purpose
- Recombinant Human Cadherin-12/CDH12 Protein (His Tag)
- Sequence
- Met 1-Ala 605
- Characteristics
- A DNA sequence encoding the pro form of human CDH12 (NP_001783.2) extracellular domain (Met 1-Ala 605) was fused with a polyhistidine tag at the C-terminus.
- Purity
- > 80 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product Cadherin 12 Protein
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Cadherin 12 (AA 55-609) protein (MBP tag)
Crystallography grade Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Cadherin 12 (AA 1-794) protein (GST tag)Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Cadherin 12 (AA 372-470) protein (GST tag)Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Cadherin 12 (AA 56-605), (partial) protein (His tag)Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 50 mM sodium citrate, 50 mM NaCl, 2 mM CaCl2, pH 6.0
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Cadherin 12
- Alternative Name
- Cadherin-12/CDH12 (Cadherin 12 Products)
- Synonyms
- CDHB Protein, Cdhb Protein, RGD1566350 Protein, cdh12 Protein, cadherin 12 Protein, cadherin-12 Protein, CDH12 Protein, Cdh12 Protein, LOC570372 Protein
- Background
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Background: Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonym: CDHB
- Molecular Weight
- 66 kDa
- NCBI Accession
- NP_001783
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