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Cadherin 8 Protein (CDH8) (His tag)

CDH8 Origin: Rat Host: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
Catalog No. ABIN7194515
  • Target See all Cadherin 8 (CDH8) Proteins
    Cadherin 8 (CDH8)
    Protein Type
    Recombinant
    Origin
    • 8
    • 3
    • 2
    Rat
    Source
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Cadherin 8 protein is labelled with His tag.
    Purpose
    Recombinant Rat Cadherin-8/CDH8 Protein (His Tag)
    Sequence
    Met1-Met621
    Characteristics
    A DNA sequence encoding the rat CDH8 (NP_445845.2) (Met1-Met621) was expressed with a polyhistidine tag at the C-terminus.
    Purity
    > 85 % as determined by SDS-PAGE
    Endotoxin Level
    < 1.0 EU per μg of the protein as determined by the LAL method
    Top Product
    Discover our top product CDH8 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Storage
    4 °C,-20 °C,-80 °C
    Storage Comment
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Cadherin 8 (CDH8)
    Alternative Name
    Cadherin-8/CDH8 (CDH8 Products)
    Synonyms
    AI851472 Protein, cad8 Protein, cadherin-8 Protein, Nbla04261 Protein, cadherin 8 Protein, cadherin 8, type 2 Protein, Cdh8 Protein, CDH8 Protein
    Background

    Background: Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I  cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I  transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.

    Synonym: CDH8

    Molecular Weight
    66.5 kDa
    NCBI Accession
    NP_445845
    Pathways
    Cell-Cell Junction Organization
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