Calsequestrin Protein
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- Target See all Calsequestrin (CASQ1) Proteins
- Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purpose
- Recombinant Human Calsequestrin-1/CASQ1 Protein
- Sequence
- Gln35-Asp396
- Characteristics
- A DNA sequence encoding the mature form of human CASQ1 (P31415) (Gln35-Asp396) was expressed with a N-terminal Met.
- Purity
- > 80 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CASQ1 Protein
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Calsequestrin 1 (CASQ1) (AA 1-390) protein (GST tag)
CASQ1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calsequestrin 1 (CASQ1) (AA 29-130) protein (GST tag)CASQ1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Calsequestrin 1 (CASQ1) (AA 35-396) protein (His tag)Crystallography grade CASQ1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Calsequestrin 1 (CASQ1) (AA 35-405) protein (His tag)Crystallography grade CASQ1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Calsequestrin 1 (CASQ1) proteinCASQ1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA, IP
Calsequestrin 1 (CASQ1) protein (Myc-DYKDDDDK Tag)CASQ1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile 50 mM Tris, 10 % glycerol, pH 7.5
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Calsequestrin (CASQ1) (Calsequestrin 1 (CASQ1))
- Alternative Name
- Calsequestrin-1/CASQ1 (CASQ1 Products)
- Synonyms
- CASQ Protein, PDIB1 Protein, casq1 Protein, CSQ Protein, CSQ-1 Protein, CSQ1 Protein, sCSQ Protein, zgc:154027 Protein, asph Protein, casq Protein, casq1.L Protein, pdib1 Protein, bZ1G18.2 Protein, zgc:100957 Protein, calsequestrin 1 Protein, Calsequestrin-1 Protein, calsequestrin 1b Protein, calsequestrin 1 S homeolog Protein, calsequestrin 1a Protein, CASQ1 Protein, casq1 Protein, Casq1 Protein, casq1b Protein, casq1.S Protein, casq1a Protein
- Background
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Background: Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-bound calcium (through a calcium release channel) triggers muscle contraction. The active protein is not highly structured, more than 50 % of it adopting a random coil conformation. When calcium binds there is a structural change whereby the alpha-helical content of the protein increases from 3 to 11 %. Both forms of calsequestrin are phosphorylated by casein kinase 2, but the cardiac form is phosphorylated more rapidly and to a higher degree. Calsequestrin-1 is also secreted in the gut where it deprives bacteria of calcium ions.
Synonym: CASQ,PDIB1,VMCQA
- Molecular Weight
- 41.8 kDa
- UniProt
- P31415
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