Cathepsin L Protein (His tag)

Catalog No. ABIN7318255

Recombinant Cathepsin L protein expressed in Human Cells.

Quick Overview for Cathepsin L Protein (His tag) (ABIN7318255)

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purification tag / Conjugate: This Cathepsin L protein is labelled with His tag.

Purpose: Recombinant Human Cathepsin L/CTSL Protein (His Tag)

Sequence: Thr18-Val333

Characteristics: Recombinant Human Cathepsin L is produced by our Mammalian expression system and the target gene encoding Thr18-Val333 is expressed with a 6His tag at the C-terminus.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM HAc-NaAc, 150 mM NaCl, pH 4.5.

Storage: -20 °C

Storage Comment: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Target Details

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: Cathepsin L/CTSL

Background:

Background: Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts and is also one of the major acidic cysteine proteases in mammalian cells.

Synonym: Cathepsin L1, Major Excreted Protein, MEP, CTSL1, CTSL

Molecular Weight: 36.9 kDa

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades